Evidence map›Paper›PMID 42792233›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Effects of Dietary Supplementation with Conjugated Linoleic Acid on Redox Marker Profiles and Neuroaxonal Degeneration in Amyotrophic Lateral Sclerosis.

Minoo Sharbafshaaer, Roberta Pepe, Elvira Cortini, Teresa Biscardi, Rosaria Notariale, Nicolò Mesini, Elisabetta Zucchi, Jessica Mandrioli, Alessandro Tessitore, Paolo Bergamo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Minoo SharbafshaaerNeurology Unit, First Division of Neurology and Neuro-Physiopathology, AOU University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-9887-5304
Roberta PepeDepartment of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vavitelli", 80138 Naples, Italy.
Elvira CortiniInstitute of Biosciences and Bio-Resources, National Research Council (CNR-IBBR), 80100 Naples, Italy.
Teresa BiscardiInstitute of Biosciences and Bio-Resources, National Research Council (CNR-IBBR), 80100 Naples, Italy.
Rosaria NotarialeNeurology Unit, First Division of Neurology and Neuro-Physiopathology, AOU University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-6048-9480
Nicolò MesiniDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Elisabetta ZucchiDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Jessica MandrioliDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy.ORCID 0000-0002-9244-9782
Alessandro TessitoreNeurology Unit, First Division of Neurology and Neuro-Physiopathology, AOU University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Paolo BergamoInstitute of Biosciences and Bio-Resources, National Research Council (CNR-IBBR), 80100 Naples, Italy.ORCID 0000-0002-1726-7911
Francesca TrojsiNeurology Unit, First Division of Neurology and Neuro-Physiopathology, AOU University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-3790-8018

Funding

European Union Next Generation EU P202224WKC
6 · The paper itself

Abstract

The revised ALS Functional Rating Scale (ALSFRS-R) and the blood plasma accumulation of neurofilament light chain (NfL) are key markers for tracking amyotrophic lateral sclerosis (ALS) progression. Based on recent studies indicating that dietary supplementation with conjugated linoleic acid (CLA) may boost antioxidant enzyme activity in ALS patients, in this study, ALSFRS-R scores (and subscores), NfL and thiol-bound protein (P-SH) levels, and intracellular activity of antioxidant enzymes (G6PD and GSR) were measured in ALS patients after 6 months (T6) of treatment with riluzole (R) or riluzole + CLA (R + CLA); we also investigated the correlations between these markers. At baseline (T0), G6PD activity in the R group was positively correlated with ALSFRS-R score (

Indexed as

ALSFRS-Ramyotrophic lateral sclerosisconjugated linoleic acidneurodegenerationneurofilament light chainNrf2-mediated redox homeostasissystemic redox biomarkers

Identifiers

PMID42792233
PMCPMC13603758

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.