ArticleBiology2026
Premature Coronary Artery Disease, Association with Relative Blood Number of Mitochondrial DNA Copies in Mexican Population-Results of GEA Study.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The mitochondrial DNA copy number (mtDNA-CN) is considered an indirect indicator of the number of mitochondria and of mitochondrial dysfunction; its decrease may indirectly reflect mitochondrial DNA (mtDNA) alterations. A reduction in mtDNA-CN is associated with the development of cardiovascular diseases, including coronary artery disease (CAD). The study evaluates the association of relative blood mtDNA-CN with premature CAD (pCAD) and cardiometabolic factors among Mexican individuals from the GEA (Genetics of Atherosclerotic Disease) Mexican cohort. Relative blood mtDNA-CN was quantified by real-time PCR in 835 patients with pCAD and 896 control subjects (defined as a coronary artery calcium score of zero, assessed by computed tomography). Associations were evaluated using logistic regression (odds ratio [95% confidence interval]) adjusted for potential confounders. Compared with controls, patients with pCAD exhibited significantly lower relative blood mtDNA-CN (5.6 [3.5-9.8] vs. 9.1 [5.1-13.2].
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