Natural Killer Cells Dominate the Hyperacute Lymphocyte Response to Major Trauma and Are Associated with Organ Dysfunction.

Joanna M Shepherd, Lucy R Gibb, Hew D T Torrance, Joanna Manson, Daniel J Pennington, Paul Vulliamy, Karim Brohi

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joanna M ShepherdCentre for Trauma Sciences, Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.

Lucy R GibbCentre for Trauma Sciences, Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.ORCID 0009-0006-1013-8865

Hew D T TorranceSection of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London W2 1NY, UK.ORCID 0000-0002-3854-1748

Joanna MansonGloucestershire Hospitals NHS Foundation Trust, Gloucester GL1 3NN, UK.

Daniel J PenningtonCentre for Immunobiology and Infection, Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.

Paul VulliamyCentre for Trauma Sciences, Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.

Karim BrohiCentre for Trauma Sciences, Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.ORCID 0000-0003-0643-8866

Funding

Wellcome TrustWellcome Trust 309168/Z/24/Z

6 · The paper itself

Abstract

The cellular immune response underlying post-injury multiple organ dysfunction syndrome (MODS) remains incompletely described. We hypothesized that early perturbations in innate lymphocyte behavior are critical to the development of MODS in trauma patients. To address this, we examined lymphocyte subsets in a prospective cohort of major trauma patients recruited at a single major trauma hospital. Circulating lymphocytes were profiled with flow cytometry in serial samples drawn within the hyperacute (≤2 h) and acute (24 h, 72 h) post-injury periods. Plasma levels of specific mediators derived from innate lymphocytes were also measured in a larger cohort. We observed a marked hyperacute increase in circulating NK (particularly the CD56

Indexed as

Killer Cells, NaturalMultiple Organ FailureWounds and InjuriesAdultAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCytokinesFemaleHumansLectins, C-TypeLymphocyte ActivationLymphocyte SubsetsMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily KAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCytokinesKLRK1 protein, humanLectins, C-TypeNK Cell Lectin-Like Receptor Subfamily Klymphocytesnatural killer cellsorgan dysfunctiontraumatic injury

Identifiers

PMID42793060

DOI10.3390/biom16091228

PMCPMC13604584

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.