ArticleBiomolecules2026
TH1177, Clemastine, and Benzhydryl Derivatives Act as Novel Extracellular Blockers of ORAI Channels.
Pengyun Li, Hussein N Rubaiy, Thomas Hallett, Yi Liang, Gui-Lan Chen, Bo Zeng, Pingping Zheng, Nawel Zaibi, Dong-Na Su, Andrew N Boa and 1 more
Abstract read
In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Hussein N RubaiyCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.ORCID 0000-0002-1489-5576 Thomas HallettCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.
Yi LiangKey Laboratory of Medical Electrophysiology, Ministry of Education and Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Gui-Lan ChenCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.
Pingping ZhengCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.
Dong-Na SuCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.
Andrew N BoaDepartment of Chemistry, School of Natural Science, University of Hull, Hull HU6 7RX, UK.ORCID 0000-0002-8002-8147 Shang-Zhong XuCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.ORCID 0000-0002-7295-9347 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
ORAI channels are store-operated Ca
Indexed as
Calcium Channel BlockersORAI1 ProteinORAI2 ProteinCalciumCalcium ChannelsHEK293 CellsHumansNeoplasm ProteinsStromal Interaction Molecule 1CalciumCalcium Channel BlockersCalcium ChannelsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanORAI2 ProteinORAI2 protein, humanOrai3 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1calcium channelsclemastinecloperastineORAI channelsstromal interaction molecule 1TH1177
Identifiers
PMID42793204
PMCPMC13604178
What Socratic holds
Textmetadata
Read underepoch 390