ArticleInternational journal of molecular sciences2026
Pulsed Electromagnetic Fields Enhance Resveratrol-Induced Apoptosis Through Modulation of Apoptotic Signaling in U87-MG Glioblastoma Cells.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by dysregulated cellular signaling and resistance to apoptosis. Pulsed electromagnetic field (PEMF) exposure has been reported to modulate cancer-related cellular processes, while resveratrol (RES), a natural polyphenol, exhibits notable antiproliferative and pro-apoptotic actions. Here, we investigated whether 75 Hz PEMF potentiates RES-mediated apoptosis in human glioblastoma U87-MG cells by examining key molecules involved in apoptotic signaling and the transcriptional responses of PI3K/AKT/mTOR pathway-related genes. U87-MG glioblastoma cells and non-tumour human astroglial SVG-P12 cells were cultured and divided into the following six groups: (I) untreated cells; (II) RES-treated cells; (III) temozolomide (TMZ)-treated cells; (IV) PEMF-exposed cells; (V) cells treated with RES followed by PEMF exposure; and (VI) cells treated with TMZ followed by PEMF exposure. Cell viability was assessed in both cell lines by alamar blue assay, and selectivity indices were derived from the resulting IC50 values. Apoptotic responses and gene expression profiles were assessed in U87-MG cells by flow cytometry and qRT-PCR, while selected apoptosis-related proteins were evaluated by Western blotting. RES treatment induced stronger cytotoxic effects than TMZ in U87-MG cells, and this response was markedly enhanced following PEMF exposure, the IC
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.