Evidence map›Paper›PMID 42794457›Full record

ArticleInternational journal of molecular sciences2026

Establishment of an In Vitro DSS-Induced Epithelial Injury Model to Investigate Dose-Dependent Effects of IL-6 and Butyrate on Barrier Function.

Srijal Kunwar, Saleh A Naser

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Srijal KunwarBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.ORCID 0009-0003-6048-9987
Saleh A NaserBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.ORCID 0000-0001-9222-4527

Funding

Florida Legislative Grant N/A
6 · The paper itself

Abstract

Dextran sodium sulfate (DSS) is widely used in vivo to induce epithelial injury; however, the epithelial-specific responses to DSS and mechanisms associated with barrier restoration remain incompletely understood. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monolayers. Exposure to 2.5%(

Indexed as

ButyratesDextran SulfateEpithelial CellsInterleukin-6Intestinal MucosaCaco-2 CellsClaudin-2ClaudinsHumansIntestinal Barrier FunctionPermeabilityReactive Oxygen SpeciesButyratesClaudin-2ClaudinsCLDN2 protein, humanDextran SulfateInterleukin-6Reactive Oxygen SpeciesbutyrateCaco-2cytokinesdextran sodium sulfate (DSS)epithelial barrierIL-6inflammatory bowel disease (IBD)

Identifiers

PMID42794457
PMCPMC13606610

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.