ArticleInternational journal of molecular sciences2026
The Association Between Vitamin D Status and Depression Severity in Adults with Major Depressive Disorder: A Cross-Sectional Study.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The implication of vitamin D in the pathophysiology of depression has generated interest regarding its role as a biomarker in the context of mental health. Given the limited data on this association in the Romanian population, the present study aimed to evaluate the correlation between vitamin D status and the severity of depressive symptomatology in a sample of adult patients from Romania. This cross-sectional study was conducted on 90 patients diagnosed with major depressive disorder who were admitted to the Department of Psychiatry at the County Clinical Emergency Hospital of Bihor during the period of 2024-2025. Serum vitamin D concentrations were determined by measuring the 25-hydroxyvitamin D metabolite in blood using the chemiluminescence microparticle immunoassay method. The severity of depressive symptomatology was quantified using two validated scales: the Beck Depression Inventory-II (BDI-II) and the Hamilton Depression Rating Scale 17 (HAM-D17). Multivariable linear regression and ordered probit regression were used to assess the relationship between vitamin D status and depression severity, with adjustments for relevant covariates. A statistically significant negative association was identified for the BDI-II scale (B = -0.3170444, β = -0.2621328,
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