Evidence map›Paper›PMID 42794803›Full record

ReviewInternational journal of molecular sciences2026

Adipokines as Regulators of Nitric Oxide Synthase Isoforms Across Organs: Emerging Implications for Gastrointestinal Motility.

Maria Caterina Baccari, Silvia Nistri, Elenia Cinelli, Donatella Mutolo, Eglantina Idrizaj

Abstract readReview
PubMed Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Caterina BaccariSection of Physiological Sciences, Department of Experimental & Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-4665-1426
Silvia NistriImaging Platform, Department of Experimental & Clinical Medicine, University of Florence, 50139 Florence, Italy.
Elenia CinelliSection of Physiological Sciences, Department of Experimental & Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-5863-7624
Donatella MutoloSection of Physiological Sciences, Department of Experimental & Clinical Medicine, University of Florence, 50134 Florence, Italy.
Eglantina IdrizajSection of Physiological Sciences, Department of Experimental & Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-2756-6552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue secretes bioactive mediators known as adipokines. Beyond their well-established roles in energy homeostasis, appetite regulation, insulin sensitivity, and inflammation, adipokines have emerged as important modulators of inter-organ communication, influencing cardiovascular, neural, immune, and respiratory functions. Growing evidence indicates that many of these effects involve nitric oxide (NO) signaling. NO is produced by three major nitric oxide synthase (NOS) isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS). Experimental evidence indicates that leptin, adiponectin, and resistin can modulate NOS expression or activity and NO bioavailability in a tissue- and context-dependent manner. In the gastrointestinal tract, these adipokines can influence nitrergic signaling and motility in

Indexed as

AdipokinesGastrointestinal MotilityNitric Oxide SynthaseAdiponectinAnimalsGastrointestinal TractHumansIsoenzymesLeptinNitric OxideResistinSignal TransductionAdipokinesAdiponectinIsoenzymesLeptinNitric OxideNitric Oxide SynthaseResistinadipokinesadiponectinenteric nervous systemgastrointestinal motilityleptinnitrergic neurotransmissionnitric oxide synthaseresistin

Identifiers

PMID42794803

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.