Evidence map›Paper›PMID 42795265›Full record

ArticleLife (Basel, Switzerland)2026

Neonatal Metformin Exposure Is Associated with Altered Adult Metabolic Responses to Hyperlipidic Diet in Male Wistar Rats.

Gustavo Henrique Doná Rodrigues Almeida, Claudio Guilherme de Assis Oliveira, Bianca Fuzeti Candian, Scarlett Rodrigues Raposo, Leticia Ferreira Barbosa, João Victor Damin, Beatriz Marques Ferreira, Lucas Paulo Jacinto Saavedra, Douglas Lopes de Almeida, Leandro Martins de Freitas and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gustavo Henrique Doná Rodrigues AlmeidaExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0003-2640-8250
Claudio Guilherme de Assis OliveiraExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Bianca Fuzeti CandianExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Scarlett Rodrigues RaposoExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Leticia Ferreira BarbosaExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
João Victor DaminExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Beatriz Marques FerreiraExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Lucas Paulo Jacinto SaavedraWeill Cornell Medicine, Cornell University, Ithaca, NY 14853, USA.
Douglas Lopes de AlmeidaExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Leandro Martins de FreitasMultidisciplinary Institute of Health, Federal University of Bahia, Vitória da Conquista 45029-094, BA, Brazil.
Silvano PiovanExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.
Paulo Cézar de Freitas MathiasExperimental Laboratory in DOHaD (LEx DOHaD), Graduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, PR, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 409165/2024-7 (INCT Call 46/2024)
6 · The paper itself

Abstract

Obesity is a multifactorial disorder with increasing global prevalence, highlighting the importance of identifying early-life factors that may influence long-term metabolic outcomes. While metformin is widely used to improve metabolic dysfunction in adulthood, whether neonatal exposure to this drug modifies adult responses to subsequent dietary challenges remains poorly understood. This exploratory study evaluated whether intraperitoneal metformin administration during the neonatal period alters adult metabolic responses to hyperlipidic diet (HL) exposure in Wistar rats. Following weaning and sex determination, male offspring (

Indexed as

DOHaD conceptmetabolic programmingmetforminobesity

Identifiers

PMID42795265
PMCPMC13608670

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.