ArticleLife (Basel, Switzerland)2026
Arterial Stiffness and Anti-NR2/GluN2 Autoantibodies to N-Methyl-D-Aspartate Receptors as Markers of Vascular Aging and Cognitive Impairment in Arterial Hypertension.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundArterial hypertension (HTN) is associated with accelerated vascular aging, cerebral microvascular injury, and cognitive decline. Anti-NR2/GluN2 (NR2) antibodies may be related to N-methyl-D-aspartate receptor (NMDAR)-mediated neuronal-ischemic injury, although their clinical significance in HTN requires further clarification.
objectiveThe aim of this study was to evaluate cross-sectional associations between arterial stiffness assessed by the cardio-ankle vascular index (CAVI), serum NR2 antibody levels, and cognitive performance assessed by the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) in patients with essential HTN and controls.
methodsThis single-center study included 175 adults aged 40-70 years: 128 patients with essential HTN and 47 controls. The median age was 58 [54; 66] years in the HTN group and 55 [47; 62] years in controls (
resultsPatients with HTN had higher CAVI values than controls (8.3 [7.3; 9.4] vs. 7.3 [6.9; 7.9];
conclusionsCAVI was higher in patients with HTN and showed modest inverse associations with cognitive scores. NR2 antibody levels were also higher in HTN; however, their relationship with cognitive impairment should be interpreted as exploratory and hypothesis-generating. Further longitudinal studies with neuroimaging are required to determine the clinical and prognostic significance of these findings.
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