ReviewLife (Basel, Switzerland)2026
Oxidative Stress in Animals: A Systematic Analysis from Signaling Pathways to Biological Effects.
Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Oxidative stress is caused by the imbalance between the generation of free reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidant defense systems, which participate in animal growth, development, disease pathogenesis, and aging. This review summarizes endogenous and exogenous triggers of ROS/RNS overproduction, as well as model animals and cell models together with oxidative stress biomarkers and detection methods. We further dissect the three-layered redox regulatory network, focusing on crosstalk among four core pathways (Nrf2-ARE, NF-κB, MAPK, PI3K/Akt) that govern cell fate via oxidative eustress or distress. Excessive ROS/RNS trigger irreversible DNA damage and metabolic disorders, leading to inflammation and apoptosis. Finally, we prospect integrating non-model animals and multi-omics to advance oxidative stress research. This work provides a comprehensive theoretical framework for animal redox biology studies.
Indexed as
Identifiers
42795381What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.