Evidence map›Paper›PMID 42795443›Full record

ReviewLife (Basel, Switzerland)2026

Advances in Regenerative Dentistry: From Biological Mechanisms to Clinical Translation.

Mariela Ramirez-Velasquez, Gabriela Del Cisne Valarezo-Chicaiza, Gabriela Cristina Astudillo-Rubio, Stephany Paladines-Calle

Abstract readReview
PubMed Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mariela Ramirez-VelasquezGrupo de Investigación e Innovación en Salud Oral Integral (GIISO), Carrera de Odontología, Universidad Politécnica Salesiana, Cuenca 010101, Ecuador.ORCID 0000-0001-7041-4346
Gabriela Del Cisne Valarezo-ChicaizaGrupo de Investigación e Innovación en Salud Oral Integral (GIISO), Carrera de Odontología, Universidad Politécnica Salesiana, Cuenca 010101, Ecuador.ORCID 0000-0003-1117-0534
Gabriela Cristina Astudillo-RubioGrupo de Investigación e Innovación en Salud Oral Integral (GIISO), Carrera de Odontología, Universidad Politécnica Salesiana, Cuenca 010101, Ecuador.
Stephany Paladines-CalleGrupo de Investigación e Innovación en Salud Oral Integral (GIISO), Carrera de Odontología, Universidad Politécnica Salesiana, Cuenca 010101, Ecuador.ORCID 0000-0001-6968-6678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in cell biology, biomaterials, and tissue engineering have expanded the possibilities of regenerative dentistry, promoting a shift from tissue replacement toward biologically driven strategies aimed at restoring tissue structure and function. This review examines advances reported between 2020 and 2025, considering their biological basis, current evidence, and level of clinical translation. Major developments include regenerative endodontics, periodontal regeneration, guided tissue and bone regeneration, platelet concentrates, bioactive biomaterials, dental stem cells and cell-free therapies, biomimetic enamel regeneration, and organoid and whole-tooth bioengineering. Although some approaches are already supported by human evidence and clinical application, others remain predominantly experimental. Importantly, favorable healing or tissue formation does not necessarily represent complete functional regeneration of the native tissue. Greater standardization, long-term clinical evidence, and reproducible therapeutic protocols are therefore needed to bridge the gap between experimental advances and predictable clinical outcomes.

Indexed as

bioactive biomaterialscell-free therapydental stem cellsoral tissue regenerationregenerative dentistryregenerative medicinetissue engineering

Identifiers

PMID42795443

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.