Early-Life Antibiotic Cocktail Intervention Alters Cecal Microbiota Composition and Metabolic Profiles in Suckling Rats.

Sen Chen, Shiyi Tian, Zhihan Dong, Xueyao Zheng, Huanhuan Shan, Tian Huan, Yuyou Duan, Jue Wang

Abstract read

In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sen ChenLaboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China.

Shiyi TianCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Zhihan DongCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Xueyao ZhengCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Huanhuan ShanLaboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China.

Tian HuanLaboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China.

Yuyou DuanLaboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China.ORCID 0000-0002-1402-7402

Jue WangCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Funding

Jiangxi Provincial Department of Science and Technology 20232BAB215055 and 20252BAC240641Ministry of Science and Technology of the People's Republic of China 2018YFA0108201National Natural Science Foundation of China 32302837Second Affiliated Hospital of South China University of Technology KY09060026 and D9194290South China University of Technology D6201880, K5180910, K5204120, and D6212440

6 · The paper itself

Abstract

The early-life lactational window is critical for gut microbial colonization, intestinal maturation, and long-term host metabolic and immune programming. Although antibiotic-induced microbiota perturbation models are widely applied to investigate microbiota function, the overall microbiota perturbation efficiency and comprehensive metabolic alterations induced by broad-spectrum antibiotics during the lactational stage remain poorly characterized. In this study, neonatal SD rat pups were continuously administered a broad-spectrum antibiotic cocktail to establish a lactational antibiotic-perturbed dysbiosis model. The early-life antibiotic intervention induced mild impairment of the intestinal structure and significantly increased the relative hindgut weight. 16S rRNA sequencing demonstrated significant reductions in microbial α-diversity, profound remodeling of gut microbial communities, extensive depletion of core beneficial genera including

Indexed as

antibiotic interventionantibiotic-perturbed dysbiosis modelgut microbiotametabolomicssuckling rat pups

Identifiers

PMID42795629

DOI10.3390/microorganisms14092048

PMCPMC13609107

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.