Evidence map›Paper›PMID 42796408›Full record

ArticleMedicina (Kaunas, Lithuania)2026

Preclinical Evaluation of Labetalol for Cutaneous Melanoma Drug Repurposing: Cytotoxic Activity in A375 Cells and Mitochondria-Associated Apoptotic Signaling.

Richard Dahma, Elena-Alina Moacă, Iasmina-Alexandra Predescu, Ana-Cristiane Dragomir, Oana-Andrada Iftode, Stela Iurciuc, Diana Haj Ali, Ioana Macaşoi, Maria Sala-Cîrtog, Iulia-Najette Crintea and 2 more

Abstract read
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Richard DahmaDepartment of Biochemistry and Pharmacology, Faculty of Medicine, Doctoral School, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timişoara, Romania.
Elena-Alina MoacăUniversity Clinic of Toxicology, Drug Industry, Management, Marketing and Dermatopharmacy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0002-2631-7028
Iasmina-Alexandra PredescuUniversity Clinic of Toxicology, Drug Industry, Management, Marketing and Dermatopharmacy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Ana-Cristiane DragomirDepartment of Biochemistry and Pharmacology, Faculty of Medicine, Doctoral School, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timişoara, Romania.
Oana-Andrada IftodeUniversity Clinic of Toxicology, Drug Industry, Management, Marketing and Dermatopharmacy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Stela IurciucEmergency City Hospital Timisoara, Gheorghe Dima Street Nr. 5, 300254 Timisoara, Romania.ORCID 0000-0003-3536-6099
Diana Haj AliUniversity Clinic of Toxicology, Drug Industry, Management, Marketing and Dermatopharmacy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Ioana MacaşoiUniversity Clinic of Toxicology, Drug Industry, Management, Marketing and Dermatopharmacy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0002-9890-2277
Maria Sala-CîrtogDiscipline of Biochemistry, Department of Biochemistry and Pharmacology, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Iulia-Najette CrinteaEmergency Clinical Municipal Hospital Timisoara, Blvd. Regele Mihai I, No. 5, 300079 Timişoara, Romania.
Alina-Doina TănaseDiscipline of Professional Legislation in Dentistry, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timişoara, Romania.
Marilena DinuţiDiscipline of Biochemistry, Department of Biochemistry and Pharmacology, Faculty of Medicine, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ApoptosisDrug RepositioningLabetalolMelanomaMitochondriaSkin NeoplasmsAntineoplastic AgentsCell Line, TumorCell SurvivalHumansMembrane Potential, MitochondrialSignal TransductionAntineoplastic AgentsLabetalolA375 cellsdrug repurposingHET-CAMlabetalolmelanomamitochondrial apoptosisβ-adrenergic antagonists

Identifiers

PMID42796408
PMCPMC13609037

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.