Synthesis and Antidiabetic Evaluation of Novel 2,4-Thiazolidinedione Derivatives Targeting Key Carbohydrate-Digesting Enzymes.

Mahendra Gowdru Srinivasa, Shreya Kanchan, Darshan S, Karthik G Pujar, Gurubasavaraj V Pujar, Prashant Nayak

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mahendra Gowdru SrinivasaNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutical Chemistry, Mangalore 575018, India.

Shreya KanchanNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutical Chemistry, Mangalore 575018, India.

Darshan SNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutical Chemistry, Mangalore 575018, India.

Karthik G PujarDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India.

Gurubasavaraj V PujarDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, India.

Prashant NayakNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutics, Mangalore 575018, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a long-term metabolic disease associated with elevated glucose levels in blood and still constitutes one of the major public health issues worldwide. Inhibition of carbohydrate-digesting enzymes like α-amylase and α-glucosidase has been found to be effective in controlling postprandial hyperglycemia. The current study focused on designing, synthesis, characterization, and evaluation of novel 2,4-thiazolidinedione derivatives (

Indexed as

alpha-AmylasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsThiazolidinedionesalpha-GlucosidasesAnimalsHumansMolecular Docking SimulationStructure-Activity Relationship2,4-thiazolidinedionealpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsThiazolidinedionesADME studiesantidiabetic activitymolecular dockingthiazolidinedione derivativesα-glucosidase inhibition

Identifiers

PMID42796447

DOI10.3390/molecules31183160

PMCPMC13609656

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.