Evidence map›Paper›PMID 42796512›Full record

ArticleMolecules (Basel, Switzerland)2026

Design, Synthesis, and Antiproliferative Evaluation of C3/C12-Modified Panaxadiol Derivatives Against Gastric Cancer Cells: Integrated Transcriptomic and Metabolomic Analyses.

Yueru Zhang, Hongqing Xie, Chenggang Shan, Jinlong Han, Fangzhou Zhao, Xianchang Wang, Yinan Qi, Xiaoyang Li, Jianhua Zhang, Feng Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yueru ZhangInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Hongqing XieInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Chenggang ShanInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Jinlong HanInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Fangzhou ZhaoInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID 0009-0008-5035-4110
Xianchang WangInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Yinan QiInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Xiaoyang LiDepartment of Applied Chemistry, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-2345-7567
Jianhua ZhangInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID 0000-0003-4097-1066
Feng ZhangInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Yun ZhouInstitute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan 250100, China.

Funding

Department of Science and Technology of Shandong Province 2024TSGC0698Department of Science and Technology of Shandong Province ZR2024QH429Shandong Provincial Agriculture Department SDAIT-20
6 · The paper itself

Abstract

Panaxadiol (PD) is a bioactive dammarane triterpenoid with limited antiproliferative potency, and systematic optimization of its C3 and C12 positions remains underexplored. Here, a stepwise, site-differentiated strategy was established by combining selective C3 esterification with late-stage C12 diversification through a chloroacetyl-piperazine linker, affording 23 PD derivatives and enabling complementary C3/C12 structure-activity analysis. Antiproliferative screening in AGS gastric cancer cells identified compounds

Indexed as

Antineoplastic AgentsDrug DesignGinsenosidesMetabolomicsStomach NeoplasmsTranscriptomeCell Line, TumorCell ProliferationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsGinsenosidespanaxadiolC3/C12 site-differentiated diversificationgastric cancerintegrated multi-omicspanaxadiolstructure–activity relationship

Identifiers

PMID42796512
PMCPMC13609390

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.