ArticleNutrients2026
Impact of a High-Protein Diet Associated with Probiotics on Lipid Profile, Oxidative Stress, and Mitochondrial Activity in Adipose and Muscle Tissues of Wistar Rats.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesHigh-protein (HP) diets may influence body composition, lipid metabolism, oxidative stress, and mitochondrial function, but their interaction with probiotics remains unclear. This study evaluated the effects of HP feeding, alone or combined with
methodsThirty-two male Wistar rats were allocated to standard diet (SD), SD plus probiotics, HP diet, or HP plus probiotics for 10 weeks. Body weight gain, food and energy intake, visceral adiposity, plasma biochemical profile, adipose tissue histology, oxidative stress markers, mitochondrial electron transport chain activity, and plasma amino acids were assessed.
resultsFood and energy intake did not differ among groups. HP-fed animals showed lower weight gain, reduced visceral fat, and lower total cholesterol and triglycerides. Probiotics modulated selected redox-related outcomes, including methylglyoxal and sulfhydryl levels, with tissue-specific responses. Complex I activity increased in adipose tissue and skeletal muscle, and plasma amino acid profiles were altered, particularly glutamate, leucine, aspartate, alanine, and methionine.
conclusionsHP feeding, with or without probiotics, modulated metabolic, redox, mitochondrial, and amino acid-related parameters in Wistar rats. These findings suggest that HP diets and probiotics may influence cardiometabolic adaptations, although tissue-specific responses and mechanisms require further investigation.
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