ArticleNutrients2026
Fatty Acid Composition, Molecular Species, and Ameliorating Effects of Tilapia Head Phospholipids on High-Fat Diet-Induced Metabolic Syndrome in Mice.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesThe fish head contains a large number of bioactive lipids for preparing functional foods. In this study, we analyzed the fatty acid components and molecular species of tilapia head phospholipids (TH-PL), and investigated the preventive effect of them on metabolic syndrome (MS).
methodsTwenty-three fatty acids were identified in TH-PL, and the percentage of n-3 PUFA and n-6 PUFA was high, occupying 48.21% of total fatty acids. And sixty-two phospholipids (PL) molecular species belonging to seven types of PL were identified using UPLC-Q-TOF-MS. The contents of the various types of TH-PL were generally in the order PC > PE > SM > PS > LPC > PI > LPE. Among them, PC (16:0/18:1), PE (P-16:0/22:4), PS (18:0/22:5), LPC (16:0), PI (16:0/20:4), LPE (18:0), and SM (d16:0/18:1) were the major molecular species of TH-PL. Moreover, animal experiments were conducted to evaluate the preventive effect of TH-PL on high-fat diet (HFD)-induced MS mice.
resultsAnimal experiments revealed that TH-PL could significantly inhibit obesity, improve insulin resistance and dyslipidemia in high-fat diet (HFD)-induced MS mice. Intake of TH-PL could also block lipid synthesis in the liver by modulating the expression of lipogenesis-related genes and proteins, such as up-regulation of AMPK and down-regulation of PPARγ, SREBP-1c, and FAS. In addition, TH-PL could relieve MS directly and indirectly by counteracting gut microbiota disturbance caused by HFD.
conclusionsThese data suggested that it may be a good choice to develop new functional foods containing TH-PL for dietary intervention in MS.
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