Evidence map›Paper›PMID 42797720›Full record

ArticleToxics2026

Network Toxicology Integrates In Vivo Evidence Linking Impaired Autophagic Clearance Involving the MTOR-TFEB Axis to Polystyrene Nanoplastic-Induced Neurotoxicity.

Na Tang, Chun Wang, Meng Zhang, Yajie Li, Yongkang Liang, Jingjing Zhang, Qiang Niu

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Na TangSchool of Public Health, Shihezi University, Shihezi 832000, China.
Chun WangSchool of Public Health, Shihezi University, Shihezi 832000, China.
Meng ZhangSchool of Public Health, Shihezi University, Shihezi 832000, China.
Yajie LiSchool of Public Health, Shihezi University, Shihezi 832000, China.
Yongkang LiangSchool of Public Health, Shihezi University, Shihezi 832000, China.
Jingjing ZhangSchool of Public Health, Shihezi University, Shihezi 832000, China.
Qiang NiuSchool of Public Health, Shihezi University, Shihezi 832000, China.ORCID 0009-0002-3465-9789

Funding

Science and Technology Program of XPCC 2024ZD025Science and Technology Program of XPCC 2025DB010the 2024 Seventh Division Huyanghe City Fiscal Science and Technology Project 2024A15the National Natural Science Foundation of China 82360671the Shihezi University International Science and Technology Cooperation Promotion Programme Project GJHZ202308the Tianshan Young Talent Scientific and Technological Innovation Team: Innovative Team for Research on Prevention and Treatment of High-incidence Diseases in Central Asia 2023TSYCTD0020
6 · The paper itself

Abstract

Long-term exposure to polystyrene nanoplastics (PS-NPs) causes neurotoxicity, but the underlying mechanisms remain unclear. We combined network toxicology, molecular docking, and in vivo experiments to investigate the role of MTOR-TFEB-regulated autophagy in PS-NP-induced neurotoxicity. Potential targets related to PS-NPs and neurodegenerative diseases were screened from public databases. Enrichment analysis indicated involvement of neurodegenerative and autophagy pathways. Protein-protein interaction and docking simulations prioritized

Indexed as

impaired autophagic clearanceMTOR-TFEB signaling pathwaynetwork toxicologyneurotoxicityPS-NPs

Identifiers

PMID42797720
PMCPMC13611230

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.