Evidence map›Paper›PMID 42797726›Full record

ArticleToxics2026

Spencer R Stinson, Jane K La Du, Dante M Perone, Sibel I Karchner, Neelakanteswar Aluru, Lisa Truong, Mark E Hahn, Robyn L Tanguay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Spencer R StinsonSinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-7684-9364
Jane K La DuSinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
Dante M PeroneSinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-0716-2187
Sibel I KarchnerBiology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.ORCID 0000-0002-5026-7614
Neelakanteswar AluruBiology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.ORCID 0000-0003-2159-3194
Lisa TruongSinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-1751-4617
Mark E HahnBiology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.ORCID 0000-0003-4358-2082
Robyn L TanguaySinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0001-6190-3682

Funding

MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
Discovering Chemical Activity Networks-Predicting Bioactivity Based on StructureR35ES031709 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2021 to 2026
$5.2M
Mechanisms Controlling Sensitivity and Resistance to Dioxin-like Compounds: Role of AIPR01ES033888 · NIEHS · WOODS HOLE OCEANOGRAPHIC INSTITUTION · PI Mark E Hahn · 2022 to 2026
$3.2M
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS R01 ES033888NIEHS NIH HHS R35 ES031709NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

The Aryl Hydrocarbon Receptor (AHR) is a versatile receptor that binds various compounds, triggering downstream transcriptional changes involved in the regulation of xenobiotic metabolism and cell fate. The Ahr Interacting Protein (AIP), also known as XAP2 and ARA9, is a molecular chaperone essential for the cytosolic retention and stabilization of the AHR. Past studies, and AIP-linked human pathologies, suggest an alternative developmental role of the AIP apart from the AHR and canonical xenobiotic response. A null mutation of the AIP in zebrafish larvae (designated as

Indexed as

aryl hydrocarbon receptoraryl hydrocarbon receptor interacting proteindevelopmenthematopoiesistranscriptomicszebrafish

Identifiers

PMID42797726
PMCPMC13611658

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.