Evidence map›Paper›PMID 42798633›Full record

ArticleFrontiers in aging2026

Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood-brain barrier disruption in dementia.

Azadeh Golduzian, Erik B Erhardt, Arvind Caprihan, John C Adair, Janice E Knoefel, Jill Prestopnik, Sasha Hobson, Sephira Ryman, Andrei Vakhtin, Kiran Bhaskar and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Azadeh GolduzianDepartment of Biology, University of New Mexico, Albuquerque, NM, United States.
Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, United States.
Arvind CaprihanThe Mind Research Network, Albuquerque, NM, United States.
John C AdairDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Janice E KnoefelDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Jill PrestopnikCenter for Memory and Aging, University of New Mexico, Albuquerque, NM, United States.
Sasha HobsonCenter for Memory and Aging, University of New Mexico, Albuquerque, NM, United States.
Sephira RymanDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Andrei VakhtinThe Mind Research Network, Albuquerque, NM, United States.
Kiran BhaskarDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Gary A RosenbergDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Research Education ComponentP30AG086404 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ELAINE L BEARER · 2024 to 2026
$17.7M
Validation of Biomarkers of Small Vessel Injury in VCIDUF1NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2021 to 2023
$6.3M
Pathobiology of Vascular Cognitive ImpairmentR01NS052305 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2006 to 2016
$4.3M
MRI and CSF Biomarkers of White Matter Injury in VCIDUH3NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2018 to 2020
$3.3M
Scientific CoreP20AG068077 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2020 to 2022
$3.1M
MRI and CSF Biomarkers of White Matter Injury in VCIDUH2NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2016 to 2017
$2.1M
Siemens MAGNETOM Prisma/Prisma fit upgradeS10OD025313 · OD · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2018
$1.5M
NCATS NIH HHS UL1 TR001449NIA NIH HHS P20 AG068077NIA NIH HHS P30 AG086404NIH HHS S10 OD025313NINDS NIH HHS R01 NS052305NINDS NIH HHS UF1 NS100598NINDS NIH HHS UH2 NS100598NINDS NIH HHS UH3 NS100598
6 · The paper itself

Abstract

Inflammation and blood-brain barrier (BBB) disruption are increasingly implicated in cognitive decline, but it remains unclear which fluid and imaging measures best capture these processes. Participants were drawn from two overlapping research programs, MarkVCID and UNM ADRC. We studied 149 participants with Alzheimer's disease, leukoaraiosis, mixed dementia, subcortical ischemic vascular dementia, or memory impairment. BBB permeability was assessed using the albumin index (Q

Indexed as

albumin indexATN(V)I frameworkblood–brain barrierdynamic contrast-enhanced MRImixed dementianeuroinflammationpermeabilityvascular cognitive impairment

Identifiers

PMID42798633
PMCPMC13612504

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.