ReviewFrontiers in chemistry2026
Current advances in metal nanoparticle-based stimuli-responsive nanotherapies.
Review in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chemical language models for early-stage drug discovery: applications, pitfalls, and future directions.Journal of computer-aided molecular design · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimuli-responsive nanotherapy (SRN) has emerged as a promising therapeutic strategy that employs nanosensitizers activated by external physical or chemical stimuli to generate reactive species for disease treatment. Among various nanosensitizers, metal nanoparticles (MNPs) have attracted considerable attention owing to their unique physicochemical properties, including tunable optical responses, catalytic activity, magnetic behavior, and high surface reactivity. These characteristics enable the construction of versatile nanoplatforms for multiple dynamic therapeutic modalities. In this review, we summarize the fundamental physicochemical properties of representative metal nanoparticles and their relevance to stimulus-responsive nanotherapies. We systematically review major therapeutic modalities, including photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), piezocatalytic therapy (PCT), magnetic hyperthermia therapy (MHT), chemodynamic therapy (CDT), and electrodynamic therapy (EDT), with emphasis on their underlying mechanisms, material design, and recent biomedical applications. We further discuss the advantages and limitations of these therapeutic strategies and highlight recent advances in multifunctional nanoplatforms that integrate multiple therapeutic mechanisms to achieve synergistic effects. The biomedical applications of these metal nanoparticle-based therapies in tumor treatment, infection control, neurological disorders, bone tissue regeneration, and cardiovascular diseases are highlighted. Finally, current challenges and future perspectives are addressed, with particular emphasis on biosafety, therapeutic efficiency, stimulus control, multimodal integration, and clinical translation. This review provides an integrated overview of metal nanoparticle-based stimuli-responsive nanotherapies and highlights opportunities for the rational design of multifunctional therapeutic platforms.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.