Evidence map›Paper›PMID 42798895›Full record

ArticleACS omega2026

Development of Antimicrobial Chitosan-Silver and Chitosan-Gold Nanocomposite Films by 3D Printing for Skin Application.

Rita de Cássia Dos Reis Schmidt, Vitória Espinosa de Oliveira, Tainá Griebler, Júlia Lazzarini Machado, Leonardo Pessoa da Silva, Henrique Trombini, Marcelo Barbalho Pereira, Cesar Liberato Petzhold, Gabrielle Aguiar Dantas, Roberto Christ Vianna Santos and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rita de Cássia Dos Reis SchmidtUniversidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Biociências, Rua Sarmento Leite 245, Porto Alegre, Rio Grande do Sul CEP 90050-170, Brazil.
Vitória Espinosa de OliveiraUniversidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre, Rio Grande do Sul CEP 90050-170, Brazil.
Tainá GrieblerUniversidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre, Rio Grande do Sul CEP 90050-170, Brazil.
Júlia Lazzarini MachadoUniversidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Biociências, Rua Sarmento Leite 245, Porto Alegre, Rio Grande do Sul CEP 90050-170, Brazil.
Leonardo Pessoa da SilvaUniversidade Federal do Rio Grande do Sul, Instituto de Física, CP 15051, Porto Alegre, Rio Grande do Sul CEP 91501-970, Brazil.
Henrique TrombiniUniversidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre, Rio Grande do Sul CEP 90050-170, Brazil.
Marcelo Barbalho PereiraUniversidade Federal do Rio Grande do Sul, Instituto de Física, CP 15051, Porto Alegre, Rio Grande do Sul CEP 91501-970, Brazil.ORCID https://orcid.org/0000-0002-1351-2430
Cesar Liberato PetzholdUniversidade Federal do Rio Grande do Sul, Instituto de Química, CP 15003, Porto Alegre, Rio Grande do Sul CEP 91501-970, Brazil.ORCID https://orcid.org/0000-0002-5919-8133
Gabrielle Aguiar DantasLaboratory of Oral Microbiology Research, Universidade Federal de Santa Maria, Av. Roraima 1000, Santa Maria, Rio Grande do Sul CEP 97105-900, Brazil.
Roberto Christ Vianna SantosLaboratory of Oral Microbiology Research, Universidade Federal de Santa Maria, Av. Roraima 1000, Santa Maria, Rio Grande do Sul CEP 97105-900, Brazil.ORCID https://orcid.org/0000-0002-0533-3483
Nadine Lysyk FunkUniversidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Av. Ipiranga 2752, Porto Alegre, Rio Grande do Sul CEP 90610-000, Brazil.
Ruy Carlos Ruver BeckUniversidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Av. Ipiranga 2752, Porto Alegre, Rio Grande do Sul CEP 90610-000, Brazil.ORCID https://orcid.org/0000-0001-6262-1097
Karina PaeseUniversidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Av. Ipiranga 2752, Porto Alegre, Rio Grande do Sul CEP 90610-000, Brazil.ORCID https://orcid.org/0000-0002-1373-9336
Monique DeonUniversidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Biociências, Rua Sarmento Leite 245, Porto Alegre, Rio Grande do Sul CEP 90050-170, Brazil.ORCID https://orcid.org/0000-0002-9889-7420

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver (AgNP) and gold (AuNP) nanoparticles are notable in nanomedicine for their unique properties and strong antibacterial effects; however, formulating them into skin-applied systems that preserve bioactivity while controlling nanoparticle exposure remains challenging. Herein, semisolid extrusion 3D printing of chitosan nanocomposite hydrogels loaded with AgNPs or AuNPs was used to manufacture personalized topical films with antimicrobial performance and minimized skin penetration risk. AgNPs and AuNPs were synthesized with comparable nanoscale dimensions (11.83 ± 3.74 nm and 11.67 ± 1.96 nm), enabling their uniform incorporation into chitosan matrices. The resulting inks presented topical-compatible pH (>4.0) and pronounced thixotropy with >90% viscosity recovery, translating into adequate performance in 3D printing. Nanoparticle incorporation afforded the tuning of properties such as swelling, mechanical behavior, and bioadhesion. Functionally, AgNP-loaded films exhibited the strongest broad-spectrum activity against

Identifiers

PMID42798895
PMCPMC13613387

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.