ReviewRSC advances2026
Next generation smart functionalized nanocomposites for ultrasensitive and real time detection of purine derived metabolic biomarkers.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The monitoring of metabolic biomarkers is currently undergoing a radical change from traditional centralized laboratory standards to decentralized point-of-care testing, particularly in the management of metabolic disorders, such as gout, and renal dysfunction. This review explores next-generation functionalized nanocomposites such as metal-organic frameworks, two-dimensional (2D) transition-metal carbides, nitrides, and carbonitrides (MXenes) and Single-Atom Nanozymes (SANs) which function as sensitive elements in sensing platforms for biomarkers detection and serve as robust, non-enzymatic mimics to address the stability challenges associated with natural enzymes. Hydrothermal and green co-precipitation methods are strategic routes to fabrication, with enhanced scalability and catalytic activity. Representative analytical benchmarks demonstrate the superior performance of these platforms for metabolic biomarkers detection achieving a picomolar limit of detection (LOD) of 102 pM for Ag-Fe
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.