ArticleClinical, cosmetic and investigational dermatology2026
Potential Causal Association Between Plasma Lipidomes and Keloid: Analysis from a Two-Sample Mendelian Randomization.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background: Keloid formation is a multifaceted biological response to skin injury characterized by fibrous connective tissue, and functional and aesthetic impairments. Recent research highlights the role of plasma lipidomes in various diseases, yet their specific relationship with keloid formation has not been extensively studied. Objective: This study aims to elucidate the causal relationship between plasma lipidomes and keloid formation using a two-sample Mendelian randomization (MR) approach. Methods: Firstly, we employed a two-sample MR framework, utilizing genetic instrumental variables (IVs) derived from large-scale genome-wide association studies (GWAS). The exposure data comprised 179 plasma lipid species measured in 7174 individuals of European ancestry, while outcome data on keloids were sourced from a GWAS involving 436,200 individuals. IVs were selected using a significance threshold of P < 1×10 Results: The analysis suggested a significant association between elevated levels of Phosphatidylcholine (O-16:0_16:0) and increased risk of keloid formation (OR 1.399, 95% CI 1.166-1.678, p-value < 0.001) by Inverse-variance weighted (IVW). Sensitivity analyses confirmed the absence of heterogeneity and significant horizontal pleiotropy, reinforcing the validity of the causal inference. Conclusion: Our findings indicate that specific lipid species, particularly Phosphatidylcholine, may be associated with an increased risk of keloid formation, highlighting a potential role of lipid metabolism in keloid pathophysiology.
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