ArticleJournal of inflammation research2026
Systemic Inflammation and White Matter Hyperintensities Associated with Cognitive Impairment in Intracranial Atherosclerotic Stenosis: A Retrospective Observational Study.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Purpose: Cognitive impairment is a common clinical symptom in individuals with intracranial atherosclerotic stenosis (ICAS), but the underlying mechanisms have not been completely elucidated. This study aimed to identify factors associated with cognitive impairment in ICAS and explore their interrelationships. Methods: A total of 129 consecutive patients with ICAS and 31 healthy controls were enrolled in this research. Among the patients with ICAS, 96 completed the Montreal Cognitive Assessment (MoCA), as did all healthy controls. Cognitive impairment was defined as MoCA <23, with scores ≥23 indicating normal function. Differences between these subgroups in peripheral blood inflammatory markers and neuroimaging features were assessed. Multivariate regression models identified independent predictors of cognitive impairment and evaluated their interrelationships. Results: Patients with ICAS exhibited significantly lower MoCA scores than the controls (18.08 vs 25.10; Conclusion: Cognitive impairment in ICAS was associated with lower LMR and greater WMH burden, suggesting potential involvement of inflammatory dysregulation and white matter injury in cognitive dysfunction among patients with ICAS.
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