ArticleCurrent microbiology2026
Whole Genome Sequencing Reveals Antibiotic Resistance Heterogeneity and Metabolic Signatures of Cutibacterium acnes in Atopic Dermatitis.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Cutibacterium acnes (C. acnes), the most abundant microbe of the skin microbiota, has been reported playing a protective role in atopic dermatitis (AD), in contrast to its proinflammatory role in acne. While antibiotic resistance in C. acnes has been extensively studied in acne, little is known about its characteristics in AD. Here, we performed an integrated genomic and functional analysis of 405 AD-derived C. acnes isolates using whole genome sequencing (WGS) and antimicrobial susceptibility testing. The result showed that antibiotic resistance genes (ARGs) were highly clustered within specific individuals and phylogenetic subtypes of C. acnes, with erm(X) being the most prevalent determinant conferring cross-resistance to erythromycin and clindamycin. To verify the high genotype-phenotype concordance (95.45%) of erythromycin and clindamycin resistance of 110 ARGs-carried C. acnes isolates, minimum inhibitory concentration (MIC) was performed. AD isolates exhibited low-level acquired resistance to tetracyclines, chloramphenicol, and fusidic acid, indicating distinct antibiotic exposure pressures in AD patients. Comparative genomic analysis and genome-wide association study both showed that metabolism and quorum sensing related pathways were enriched in pan-genome of ARG-containing strains. These findings suggest that resistance in AD-associated C. acnes is linked to metabolic adaptations that may facilitate survival in the AD skin environment. Together, these findings provide a genomic and functional framework for understanding the antibiotic resistance of AD-associated C. acnes, underscoring the need for careful antibiotic stewardship in AD management.
Indexed as
Identifiers
42800844What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.