ArticleAIDS research and treatment2026
Age-Related Variations in Clinical and Biochemical Profiles of People Living With HIV.
Article in AIDS research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
People living with HIV (PLHIV) are at increased risk of liver and kidney dysfunction due to chronic HIV infection, long-term antiretroviral therapy (ART), and persistent immune activation. However, age-related differences in organ function and treatment outcomes remain insufficiently characterized in African settings. This study aimed to assess age-related differences in liver and renal function among PLHIV in Ghana to identify patterns of organ dysfunction across different age groups. This multicenter cross-sectional study included 558 PLHIV aged 10-76 years receiving ART, of whom 96.4% were on dolutegravir-based regimens. Renal function was assessed using serum urea, creatinine, urea-to-creatinine ratio, and estimated glomerular filtration rate (eGFR). Liver function was assessed using AST/ALT ratios, hepatotoxicity grading, and fibrosis indices (APRI, FIB-4), while virologic outcomes were assessed using HIV viral load measurements. A composite renal-hepatic-virologic abnormality score was developed based on reduced kidney function (eGFR < 60 mL/min/1.73 m
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