Evidence map›Paper›PMID 42801437›Full record

ArticleInternational journal of hematology2026

Prognostic impact of P-m-EASIX at neutrophil engraftment after allogeneic hematopoietic stem cell transplantation.

Kohei Okamura, Yukinori Nakamura, Shota Nono, Yuka Fujioka, Kaoru Yamamoto, Yoshihiro Tokunaga, Taishi Ando, Hiroko Nakabayashi, Yasuharu Ohta, Toshiaki Yujiri

Abstract read
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In one paragraph

Article in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kohei OkamuraThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Yukinori NakamuraThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan. nakay@yamaguchi-u.ac.jp.ORCID http://orcid.org/0000-0001-5498-3370
Shota NonoThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Yuka FujiokaThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Kaoru YamamotoThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Yoshihiro TokunagaThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Taishi AndoThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Hiroko NakabayashiThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Yasuharu OhtaThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Toshiaki YujiriThird Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the Endothelial Activation and Stress Index (EASIX) correlates with patient outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT), its prognostic value at neutrophil engraftment remains unclear. Elevated C-reactive protein (CRP) levels and hypophosphatemia at neutrophil engraftment correlate with worse outcomes after allo-HSCT. P-m-EASIX, which incorporates CRP, phosphorus, lactate dehydrogenase, and platelet count, may therefore correlate with outcomes after allo-HSCT. We retrospectively investigated the association between P-m-EASIX at neutrophil engraftment and outcomes in 114 patients who underwent their first allo-HSCT at our institution. P-m-EASIX at neutrophil engraftment was significantly higher in non-survivors than in survivors after allo-HSCT. In multivariate analyses, a P-m-EASIX ≥ 0.24 at neutrophil engraftment was an independent predictor of poor overall survival (hazard ratio [HR], 2.79; 95% confidence interval [CI], 1.56-4.99; P < 0.01) and an independent risk factor for non-relapse mortality (HR, 3.66; 95% CI, 1.33-10.06; P = 0.01). This study shows that the P-m-EASIX at neutrophil engraftment correlates with outcomes after allo-HSCT.

Indexed as

Allogeneic hematopoietic stem cell transplantationEndothelial activation and stress indexNeutrophil engraftmentNon-relapse mortalityOverall survival

Identifiers

PMID42801437

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.