Evidence map›Paper›PMID 42801545›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

PLXDC2 siRNA-Mediated Intervention Attenuates Microglial Senescence Through cGAS-STING Signaling.

Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Heyue Lu *Department of Radiology, Affiliated Hospital and Medical School of Nantong University, Nantong, People's Republic of China.
Zitian Zheng *Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, People's Republic of China.
Feiran Wang *Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, People's Republic of China.
Huanhuan LuoSchool of Nursing, Peking University, Beijing, People's Republic of China.
Fei JuResearch Center of Clinical Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, People's Republic of China.
Yucheng ZhuDepartment of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, People's Republic of China.
Zheng ZhouDepartment of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, People's Republic of China.
Jie SunResearch Center of Clinical Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, People's Republic of China.
Zhenghui QiuDepartment of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, People's Republic of China.
Xiang LuoResearch Center of Clinical Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, People's Republic of China.
Zhongzheng JiaDepartment of Radiology, Affiliated Hospital and Medical School of Nantong University, Nantong, People's Republic of China.
Jianquan WangDepartment of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, People's Republic of China.
Hongjie HuangDepartment of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, People's Republic of China.
Bo ZhangDepartment of General Surgery, Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, People's Republic of China.

Funding

Jiangsu Provincial Health Commission BJ23030Jiangsu Provincial Research Hospital YJXYY202204-YSB73National Natural Science Foundation of China 82272571National Natural Science Foundation of China 82372418Peking University Clinical Scientist Training Program BMU2025PYJH045
6 · The paper itself

Abstract

Parkinson's disease (PD) is driven by neurodegeneration, iron accumulation, and microglial senescence, yet effective therapy is hindered by the blood-brain barrier (BBB). By constructing the largest-to-date single-cell atlas of the human substantia nigra, we identified a marked upregulation of PLXDC2 in PD microglia. Leveraging this finding, we developed a multifunctional biomimetic nanoplatform (HFn-GM@siPLXDC2/DFO/CeO

Indexed as

cellular senescencecerium dioxideferritinmicrogliaparkinson's disease

Identifiers

PMID42801545
PMCPMC13616238

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.