Evidence map›Paper›PMID 42801582›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Mitochondria-Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation.

Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuanyuan SuDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-4477-8001
Zhiyan GongDepartment of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiao MuDepartment of Nephrology, University-Town Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0002-4402-0241
Lili HuangDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Pengfei YangDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-0555-8372
Chenli ZhangDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lingshan ZhaoDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liling YangDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jun DengDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-9951-2393
Xiaohui LiaoDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-2329-0456

Funding

CQMU Program for Youth Innovation in Future Medicine W0173Excellent Young Scientists Fund of the National Natural Science Foundation of China 82222039Medical Research Projects and Youth Innovation Projects of Sichuan Medical Association Q20250052National Natural Science Foundation of China 82222039National Natural Science Foundation of China 82570849Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0183
6 · The paper itself

Abstract

Mitochondria, as organelles with a critical role in maintaining cellular activities, are also vulnerable to dysfunction, which contributes substantially to the pathogenesis of various systemic diseases. Nanomaterials, owing to their tunable physicochemical properties and precise bio-interfacial capabilities, offer innovative platforms not only for delivering general mitochondria-targeted therapy but also for enabling-with promising potential-the emerging paradigms of mitochondrial transfer and transplantation. Nevertheless, a dedicated review systematically summarizing progress in this specific subfield is lacking. To fill this knowledge gap, this review provides a structured synthesis that spans from the biological basis of mitochondrial function and transfer to the broad applications of nanomaterials in mitochondria-targeted therapies, with a dedicated analysis of their roles in mitochondrial targeting, functional modulation, and gene editing. A key topic of this review is the emerging role of nanomaterials in assisting mitochondrial transplantation and transfer. By integrating these insights, this work bridges nanotechnology and mitochondrial medicine, offering a valuable resource for developing organelle-specific therapeutics.

Indexed as

mitochondriamitochondrial transfermitochondrial transplantationnanomaterialsnanotherapeutics

Identifiers

PMID42801582
PMCPMC13616353

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.