Evidence map›Paper›PMID 42801585›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Asymmetric Structure-Driven Functional Synergy: A Multistimuli-Activated Janus Nanomotor for Self-Amplifying NO Cascade Therapy.

Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chengcheng LiDepartment of Colorectal and Anal Surgery, Zhejiang-Finland Joint Laboratory of Gastrointestinal Tumor Metabolism and Nutrition, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID https://orcid.org/0009-0006-9900-8804
Yu ZhangPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.ORCID https://orcid.org/0009-0005-4213-8045
Yu ChenPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.ORCID https://orcid.org/0000-0001-7672-6762
Lingyun HeDepartment of Colorectal and Anal Surgery, Zhejiang-Finland Joint Laboratory of Gastrointestinal Tumor Metabolism and Nutrition, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xian ShenDepartment of Colorectal and Anal Surgery, Zhejiang-Finland Joint Laboratory of Gastrointestinal Tumor Metabolism and Nutrition, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID https://orcid.org/0000-0003-1164-4832
Weijian SunDepartment of Colorectal and Anal Surgery, Zhejiang-Finland Joint Laboratory of Gastrointestinal Tumor Metabolism and Nutrition, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hongbo ZhangDepartment of Colorectal and Anal Surgery, Zhejiang-Finland Joint Laboratory of Gastrointestinal Tumor Metabolism and Nutrition, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-1071-4416

Funding

Academy of Finland including Research Project 347897InFLAMES Flagship 337531'Printed Intelligence Infrastructure'Solutions for Health Profile 336355
6 · The paper itself

Abstract

Nitric oxide (NO)-based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli-activated Janus nanomotor was developed to interconnect nonenzymatic and enzymatic NO-generation pathways, enabling in situ self-cascading NO production. The nanomotor comprises an AuPt

Indexed as

cancer therapygas therapynanomotorNOphotothermal therapy

Identifiers

PMID42801585
PMCPMC13616278

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.