Evidence map›Paper›PMID 42801622›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Salvianolic Acid a Disrupts the HSP90α-AKT-PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells.

Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiuya GuanCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID https://orcid.org/0009-0008-2104-4252
Mengkai LuFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xinhai CuiCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID https://orcid.org/0000-0002-1001-6693
Dawei ZhangCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Lei ZhangFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID https://orcid.org/0000-0003-3132-3809
Lin LinInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yuan LiInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yuanlong HuInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID https://orcid.org/0000-0003-1933-7570
Chao LiCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID https://orcid.org/0000-0003-1568-9704

Funding

China Postdoctoral Science Foundation 2024M751904China Postdoctoral Science Foundation 2025T181071National Nature Science Foundation of China 82374408Shandong Provincial Natural Science Foundation ZR2025QB42Special Fund for Taishan Scholar Project tsqn202408173
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease driven by senescent vascular smooth muscle cells (VSMCs). Salvianolic acid A (SAA) exhibits cardiovascular protective effects; however, its role in atherosclerosis remains unclear. This study aimed to investigate the effects and targets of SAA in atherosclerosis. In vitro studies were performed in senescent VSMCs with heat shock protein 90 alpha (HSP90α) overexpression or knockdown, with or without SAA treatment. In vivo, ApoE

Indexed as

AKT‐PERKatherosclerosisendoplasmic reticulum‐mitochondria contactsHSP90αsenescence

Identifiers

PMID42801622
PMCPMC13616349

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.