Evidence map›Paper›PMID 42801678›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Acid-Responsive Nanobot-Integrated Core-Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis.

Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lu Tan *Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID https://orcid.org/0009-0006-7654-8533
Yan Zheng *Chongqing Yuyue Scientific Research Center for Pathology, Jinfeng Laboratory, Chongqing, China.
Yue LanSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Zhuo ChengDepartment of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China.
Siya WangDepartment of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China.
Changqing LiDepartment of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-9423-9105
Yanqiu WangDepartment of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-4384-0766
Minghan LiuDepartment of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-8572-7668

Funding

Chongqing Municipal Natural Science Foundation CSTB2025NSCQ-GPX0056Chongqing Municipal Natural Science Foundation CSTB2025NSCQ-GPX0589Chongqing Special Funding for Postdoctoral Research Projects 2025CQBSHTB3010Discipline Talent Construction Project of Xinqiao Hospital 2025XKRC013National Natural Science Foundation of China 82472445National Natural Science Foundation of China 82502900Young Doctoral Talent Cultivation Program of Xinqiao Hospital 2025YQB004
6 · The paper itself

Abstract

Annulus fibrosus (AF) rupture is a key structural event in intervertebral disc degeneration, but effective repair is hindered by the acidic, hypoxic and oxidative microenvironment of the avascular disc. Single-cell transcriptomic reanalysis and clinical AF specimens identified ferroptosis-associated redox imbalance as a prominent feature of advanced degeneration. Here, we developed an acid-responsive nanobot-integrated core-shell microneedle system for staged annulus fibrosus repair. The shell layer released TA@MgO

Indexed as

acid‐responsive nanobot‐integrated core‐shell microneedle systemannulus fibrosus regenerationATF3 promoter methylationDNMT3A‐ATF3‐SLC7A11 axisferroptosis resistancemicroenvironment reprogramming

Identifiers

PMID42801678
PMCPMC13616280

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.