Evidence map›Paper›PMID 42801717›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Remote Ischemic Post-Conditioning Preserves the Neurovascular Unit by Brain-Derived Gas6 That Drives Monocyte-Derived Macrophage Reprogramming via Axl and Vimentin after SAH.

Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yajun Zhu *Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-9153-9930
Zichao Huang *Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xi Rong *West China Hospital, Sichuan University, Sichuan, China.
Xingwei Lei *Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Fuming LiangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaoguo LiDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiru ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-7100-9665
Yu WangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yifan HuangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0006-2054-8569
Shuang TangDepartment of Cerebrovascular Diseases, Suining Central Hospital, Sichuan, China.
Jianjun ZhongDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jin YanDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-0378-1362
Hongji DengDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-7624-0487
Chun ZengDepartment of Cerebrovascular Diseases, Suining Central Hospital, Sichuan, China.
Zongduo GuoDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-3415-9293

Funding

Chongqing Natural Science Foundation Joint Fund for Innovation and Development CSTB2023NSCQ-LZX0041Doctoral Innovation Research Project of the First Clinical College of Chongqing Medical University CYYY-BSCX202514Health Commission of Sichuan Province Medical Science and Technology Program 25QNMP069National Natural Science Foundation of China 82471314
6 · The paper itself

Abstract

Subarachnoid hemorrhage (SAH) causes long-term cognitive dysfunction due to early brain injury, but effective therapies are limited. Remote ischemic post-conditioning (RIPostC) confers neuroprotection, but its mechanisms remain incompletely understood. Here we show that RIPostC preserves the neurovascular unit by modulating monocyte-derived macrophages (MDMs) via the Gas6/Axl/Vimentin axis. In 405 SAH patients, elevated cerebrospinal fluid leukocyte counts correlate positively with Hunt-Hess and 3-month mRS scores. In a rat SAH model, RIPostC suppresses periventricular CCR2

Indexed as

AxlGas6monocyte‐derived macrophagesneurovascular unitremote ischemic post‐conditioningsubarachnoid hemorrhageVimentin

Identifiers

PMID42801717
PMCPMC13616258

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.