Evidence map›Paper›PMID 42801762›Full record

ArticleChemistry & biodiversity2026

Protective Effects of Duchesnea chrysantha Ethanol Extract Against UVB-Induced Skin Damage via Modulation of TAK1-Associated Signaling Pathways.

Yerkyesh Khamit, Lei Huang, Yena Oh, Jinghan Su, Dilda Kaskadamova, Segon Jang, Weizhaole Wei, Sarah Lee, Eun Sil Kim, Youn Kyoung Son and 3 more

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yerkyesh Khamit *Department of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea.
Lei Huang *Department of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea.
Yena OhDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea.
Jinghan SuDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea.ORCID https://orcid.org/0009-0003-6210-9001
Dilda KaskadamovaDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea.
Segon JangDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea.
Weizhaole WeiDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea.
Sarah LeeNational Institute of Biological Resources, Environmental Research Complex, Incheon, Republic of Korea.
Eun Sil KimNational Institute of Biological Resources, Environmental Research Complex, Incheon, Republic of Korea.ORCID https://orcid.org/0000-0002-4534-0872
Youn Kyoung SonNational Institute of Biological Resources, Environmental Research Complex, Incheon, Republic of Korea.
Byong Chul YooDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea.ORCID https://orcid.org/0000-0001-7937-0167
Jongsung LeeDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea.ORCID https://orcid.org/0000-0002-5073-2619
Jae Youl ChoDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea.ORCID https://orcid.org/0000-0001-8141-9927

Funding

Ministry of Climate, Energy and Environment (MCEE) of the Republic of Korea NIBR202419202Ministry of Climate, Energy and Environment (MCEE) of the Republic of Korea NIBR202619101National Institute of Biological Resources
6 · The paper itself

Abstract

Duchesnea chrysantha (Zoll. & Moritzi) Miq. (Rosaceae) has traditionally been used in East Asian medicine for inflammatory and skin-related disorders. This study investigated the phytochemical composition and protective effects of D. chrysantha ethanol extract (Dc-EE) against ultraviolet B (UVB)-induced skin damage. Untargeted LC-MS/MS analysis tentatively annotated various phytochemical constituents, including flavonoids and phenolic acids. Dc-EE reduced UVB-induced oxidative stress, reactive oxygen species production, and apoptosis in human keratinocytes (HaCaT) and dermal fibroblasts (HDF). It also suppressed cyclooxygenase-2 and matrix metalloproteinases (MMP-1, MMP-2, and MMP-9) in HaCaT cells while restoring collagen type I alpha 1 expression in HDF cells. In addition, Dc-EE enhanced the expression of skin barrier- and hydration-related factors, including filaggrin, transglutaminase-1, and hyaluronan synthase-2. Dc-EE attenuated UVB-induced MAPK signaling by reducing JNK, ERK, and p38 phosphorylation, together with AP-1 and NF-κB transcriptional activities. Reduced activation of transforming growth factor-β-activated kinase 1, an upstream stress-responsive regulator, was also observed. These findings indicate that Dc-EE attenuates UVB-induced cellular damage through antioxidant, anti-inflammatory, and barrier-related effects, supporting its potential for skin protection.

Indexed as

MAP Kinase Kinase KinasesPlant ExtractsProtective AgentsRosaceaeSkinUltraviolet RaysApoptosisCell LineEthanolHumansKeratinocytesMAP Kinase Kinase Kinase 7Oxidative StressReactive Oxygen SpeciesSignal TransductionEthanolMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesPlant ExtractsProtective AgentsReactive Oxygen SpeciesDuchesnea chrysanthaoxidative stressphytochemical extractskin barrier functionTAK1‐associated signalingUVB‐induced skin damage

Identifiers

PMID42801762
PMCPMC13616469

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.