SynthesisNature communications2026
Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.
Synthesis in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Psoriasis is a heritable, common chronic autoimmune disorder characterized by cycles of remission and flare-ups. Here, we jointly analyze genomic and single-cell transcriptomic data to elucidate the genetic and molecular architecture of psoriasis. We perform a large-scale genome-wide meta-analysis of individuals of European ancestry (n = 1,131,685) and identify 125 independent susceptibility loci associated with psoriasis, including 17 previously unreported loci. Integrating these findings with single-cell transcriptome data identifies the predominant roles of myeloid and T cells in psoriasis and the enriched expression of disease-associated genes in keratinocytes and endothelial cell subsets. Finally, we prioritize 50 potential therapeutic target genes using multiple robust approaches and identify their cell subtype-specific activity patterns across non-lesional, lesional, and treatment conditions, thereby revealing layer-specific cross-cell-type interactions in psoriasis. These findings provide perspectives regarding the pathogenesis of psoriasis and highlight the role of immunometabolism in disease progression.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.