Evidence map›Paper›PMID 42802563›Full record

ArticleClinical pharmacology and therapeutics2026

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV-1 Latency Reversal.

Lauren A R Tompkins, Amanda Poliseno, Airlie Ward, Edward P Browne, Cassandra Gilbert, Craig Sykes, Angela D M Kashuba, Mackenzie L Cottrell

Abstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren A R TompkinsDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0009-0002-8503-9686
Amanda PolisenoDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0009-0006-0150-0500
Airlie WardUNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0009-0007-7378-7587
Edward P BrowneUNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-9070-7015
Cassandra GilbertDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Craig SykesDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0009-0002-9372-2784
Angela D M KashubaDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-9171-8493
Mackenzie L CottrellDepartment of Pharmacy: Clinical & Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, USA.ORCID https://orcid.org/0000-0002-0291-5111

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Accelerating to the Cure: A Novel IVIVE Model for Advancing HIV Eradication StrategiesR21AI157853 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTRELL, MACKENZIE · 2021 to 2022
$424k
National Institute of Allergy and Infectious Diseases R21 AI157853NCI NIH HHS P30 CA016086NIAID NIH HHS P30 AI050410NIAID NIH HHS R21 AI157853UNC Center for AIDS Research P30 AI050410
6 · The paper itself

Abstract

Romidepsin (RMD), an FDA-approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency-reversing activity in vitro but has yielded suboptimal outcomes in kick-and-kill HIV-cure trials when administered as a 5 mg/m

Identifiers

PMID42802563
PMCPMC13617262

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.