ArticleVirulence2026
Integrated multi-omics analysis identifies PPAR signaling network associations with metabolic-immune dysregulation and intestinal injury in PDCoV-infected piglets.
Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus that causes severe diarrhea and high mortality in neonatal piglets and has demonstrated the capacity to infect human cells. However, the host response networks that govern disease outcome remain poorly understood. Here, we performed integrated transcriptomic, proteomic, and metabolomic profiling of jejunal tissues from PDCoV-infected piglets, representing the first such analysis in the primary target organ of this pathogen. Multi-omics integration identified a core host-response network characterized by concurrent activation of a potent type I interferon-mediated antiviral response and notable alterations in lipid metabolism. The peroxisome proliferator-activated receptor (PPAR) signaling pathway was among the most significantly enriched pathways, marked by coordinated upregulation of
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