Evidence map›Paper›PMID 42803516›Full record

ArticleeLife2026

Selective lifelong suppression of an odor processing channel in response to critical period experience.

Hans C Leier, Julius Jonaitis, Alexander J Foden, Abigail J Wilkov, Paola Van der Linden Costello, Heather T Broihier, Andrew M Dacks

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hans C Leier *Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0002-0363-1444
Julius Jonaitis *Department of Biology, Case Western Reserve University, Cleveland, United States.ORCID https://orcid.org/0000-0002-1703-9396
Alexander J Foden *Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0001-7244-619X
Abigail J WilkovDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0009-0006-4307-0748
Paola Van der Linden CostelloDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0009-0000-6972-3707
Heather T BroihierDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0003-1363-3088
Andrew M DacksDepartment of Biology, Case Western Reserve University, Cleveland, United States.ORCID https://orcid.org/0000-0002-6805-4211

Funding

Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Medical Scientist Training Program at Case Western Reserve UniversityT32GM152319 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Heather Broihier, Alex Yee-Chen Huang · 2024 to 2026
$5.1M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
The Receptor Basis for Serotonergic Modulation of Olfaction Across Multiple BrainAreasR01DC016293 · NIDCD · WEST VIRGINIA UNIVERSITY · PI DACKS, ANDREW M · 2018 to 2022
$2.1M
Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespanR01NS120689 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BROIHIER, HEATHER · 2021 to 2025
$2.0M
Investigating glial priming by an early-life sensory experienceF30AG097357 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI Hans Christian Leier · 2025 to 2026
$110k
NIA NIH HHS F30 AG097357NIDCD NIH HHS R01 DC016293NIGMS NIH HHS T32 GM152319NIH HHS F30AG097357NIH HHS R01DC016293NIH HHS R01NS120689NIH HHS T32GM152319NIMH NIH HHS RF1 MH117815NINDS NIH HHS R01 NS120689NINDS NIH HHS U24 NS126935
6 · The paper itself

Abstract

Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the

Indexed as

Drosophila melanogasterDrosophila ProteinsNeuronal PlasticityOdorantsOlfactory Receptor NeuronsReceptors, OdorantSmellAnimalsNeurogliaPhagocytosisDrosophila ProteinsReceptors, Odorantantennal lobecritical periodD. melanogasterDrosophilaneuroscienceolfaction

Identifiers

PMID42803516
PMCPMC13619131

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.