ArticleJournal of obesity2026
Joint Association of Inflammatory-Metabolic Indices With Risk of Incident Stroke Among Middle-Aged and Older Chinese Adults.
Article in Journal of obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Joint Association of Inflammatory-Metabolic Indices With Risk of Incident Stroke Among Middle-Aged and Older Chinese Adults.Journal of obesity · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the independent and joint associations of the C-reactive protein-triglyceride-glucose index (CTI) and the Chinese visceral adiposity index (CVAI) with incident stroke. Additionally, we evaluated whether a novel combined index, CTI-CVAI, outperforms the established TyG-CVAI in predicting stroke risk. MATERIALS AND
methodsThis cohort study included 8267 stroke-free participants from the China Health and Retirement Longitudinal Study (CHARLS). Cox proportional hazards models, Kaplan-Meier curves, and restricted cubic splines were utilized to analyze associations with incident stroke. Additive and multiplicative interactions between CTI and CVAI were examined. Predictive performance was assessed via receiver operating characteristic (ROC) analysis, comparing CTI-CVAI against TyG-CVAI using DeLong's test and the Boruta algorithm for feature importance.
resultsDuring a mean follow-up of 8.37 years, 816 incident stroke cases were identified. Elevated CTI and CVAI were independently associated with increased stroke risk in a linear dose-response manner, without significant interaction. The novel CTI-CVAI index exhibited a robust association with stroke; participants in the highest tertile had a 2.14-fold higher risk (HR 2.14, 95% CI 1.75-2.62) compared to the lowest. Crucially, CTI-CVAI demonstrated superior predictive accuracy (AUC 0.627) over the established TyG-CVAI index (P = 0.002), a finding supported by consistent results across subgroups.
conclusionsCTI and CVAI are independent risk factors for stroke, and their combination (CTI-CVAI) offers enhanced predictive value, outperforming the TyG-CVAI index. Monitoring CTI-CVAI may serve as a superior strategy for early risk stratification and targeted stroke prevention in middle-aged and elderly populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.