ArticleProceedings of the National Academy of Sciences of the United States of America2026
Spatiotemporally primed coelomic epithelium and supporting-like cells establish the dual origin of granulosa cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Spatiotemporally primed coelomic epithelium and supporting-like cells establish the dual origin of granulosa cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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17 authors.
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Abstract
Ovarian organogenesis relies on the coordinated specification of supporting and steroidogenic lineages from multipotent progenitors of the coelomic epithelium. However, how these progenitors adopt distinct fates and differentiate into pregranulosa cells and steroidogenic progenitors of theca cells remain poorly understood. Here, we show that the dynamics of ovarian somatic lineage specification are conserved between human and mouse. Coelomic epithelial cells covering the fetal ovaries are heterogeneous and already biased toward supporting or steroidogenic fates. This priming is spatially and temporally organized, influenced by proximity to the mesonephros, and characterized by a transient coexistence of both progenitor types before resolving into predominantly supporting-biased cells. In mice, local delamination of these primed epithelial progenitors seeds intragonadal domains that give rise to pregranulosa and steroidogenic progenitors. We further demonstrate that these fetal steroidogenic progenitors generate adult stromal and theca cells. In addition, we uncover that granulosa cells arise from two distinct sources: Coelomic epithelium
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