ArticleToxicology and applied pharmacology2026
A longitudinal characterization of cardiopulmonary and systemic injury following acute chlorine inhalation in rats.
Gajanan R Jadhav, Amber J Johns, Iram Zafar, Aftab Ahmad, Shama Ahmad
Abstract read
In one paragraphArticle in Toxicology and applied pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Gajanan R JadhavDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Amber J JohnsDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Iram ZafarDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Aftab AhmadDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Shama AhmadDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: shamaahmad@uabmc.edu.
Funding
Novel lead compound advancement for mitigating halogen-induced mortality and morbidity.U01ES033263 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Shama Ahmad · 2022 to 2026
$3.6MTargeting cardiopulmonary calpains to mitigate toxicity of halogen gases.U01ES028182 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMAD, SHAMA, DELL'ITALIA, LOUIS J. · 2017 to 2019
$1.3MExtracellular vesicles as mediators of injury in inhaled exposures to toxic chemicals.R56ES034423 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMAD, AFTAB, AHMAD, SHAMA · 2023 to 2023
$446kAirway stem cell activation in the mitigation of halogen-induced lung injuryR21ES030525 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMAD, SHAMA · 2020 to 2021
$408kNovel therapeutic targets for fluoroacetate-induced toxicities.R21ES032353 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMAD, AFTAB · 2020 to 2021
$408kNIEHS NIH HHS R21 ES030525NIEHS NIH HHS R21 ES032353NIEHS NIH HHS R56 ES034423NIEHS NIH HHS U01 ES028182NIEHS NIH HHS U01 ES033263
6 · The paper itselfAbstract
Chlorine is a highly reactive, toxic industrial gas whose accidental or intentional release poses a significant public health threat, highlighting the need for effective medical countermeasures. Well-characterized animal models are essential for understanding the mechanisms of chlorine-induced injury and evaluating potential therapeutics. In this study, we established a longitudinal preclinical rat model of acute chlorine inhalation using two near lethal (LD
Indexed as
ChlorineHalogenInhaledInjuryOrgan DamagePulmonaryRodentSystemic
Identifiers
PMID42805570
PMCPMC13656749
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