ReviewCommunications biology2026
Arthritis models for studying chikungunya virus joint inflammation.
Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Chikungunya virus (CHIKV) joint inflammation remains poorly understood, despite its clinical burden. This review surveys in vitro joint models which were originally developed for arthritis research and examine how they can be repurposed to study CHIKV joint pathology. We outline key considerations, limitations, and recommendations for adapting these models for infection studies, including facilitating infection susceptibility across joint models, tuning matrix composition, addressing cellular incompleteness through modeling relevant immune cells, improving culture longevity and reproducibility. Together, these models offer versatile and human-relevant approaches to replicate key features of joint inflammation in advancing the understanding of CHIKV-induced joint pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.