Multi-omics integration of proteomics and metabolomics in pediatric health and disease.

Andrei M Matusa, David Tweddell, Mark Daley, David B O'Gorman, Douglas D Fraser

Abstract readReview

In one paragraph

Review in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrei M MatusaPhysiology and Pharmacology, Western University, London, ON, Canada.ORCID http://orcid.org/0009-0000-2274-3321

David TweddellComputer Science, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0001-6061-2285

Mark DaleyComputer Science, Western University, London, ON, Canada.

David B O'GormanChildren's Health Research Institute, London, ON, Canada.ORCID http://orcid.org/0000-0001-6195-2644

Douglas D FraserPhysiology and Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.ORCID http://orcid.org/0000-0002-5635-3791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Personalized medicine is essential for delivering efficacious care to children, yet pediatric-specific research and treatment guidelines lag behind those for adults. Multi-omics integration may offer clinicians biologically grounded patient stratification beyond traditional clinical biomarkers. While this approach holds promise for advancing precision medicine, it remains incompletely validated, and significant barriers to routine clinical implementation persist. In this review, we discuss practical considerations for integrating proteomics and metabolomics in pediatric multi-omics research. We describe popular code- and web-based tools, and recent examples of multi-omics studies in pediatric cohorts, concluding with current challenges and future outlooks for integrative multi-omics studies.

Identifiers

PMID42806057

DOI10.1038/s43856-026-01934-7

PMCPMC13620128

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.