Evidence map›Paper›PMID 42806145›Full record

ArticleNature genetics2026

A human single-cell atlas identifies OLR1

Eleni Papachristoforou, Kexin Kong, Fabio Colella, Jacky Tam, Juliet Luft, Ravi Parhar, Yingxin Liang, Ailish McCafferty-Brown, George Finney, Keshav Rao and 33 more

Abstract read
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In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Eleni Papachristoforou *Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Kexin Kong *Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Fabio Colella *Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Jacky TamCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Juliet LuftCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2458-9377
Ravi ParharCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Yingxin LiangDepartment of Physiology and Pharmacology, Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Ailish McCafferty-BrownCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
George FinneyInstitute of Infection, Immunity and Transplantation, University College London, London, UK.
Keshav RaoInstitute of Infection, Immunity and Transplantation, University College London, London, UK.
Jayamary Divya RavichandarGilead Sciences, Foster City, CA, USA.
Elena F SutherlandCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Stefan VeizadesCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3829-3537
Malgorzata GrzelkaCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Pak Kwan QiuCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0009-0001-8900-0319
Ayma AsifCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Ines BattleCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Max HammerCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Theresa KuschnereitCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Raktaprabal KashyapCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Sebastian J WallaceCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
John R Wilson-KanamoriCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1372-9912
Ginerva PistocchiInstitute of Infection, Immunity and Transplantation, University College London, London, UK.ORCID http://orcid.org/0009-0004-7749-785X
Tabitha Turner-StokesGenetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.
Alvile KasarinaiteCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Josepmaria ArgemiCIBERehd, Madrid, Spain.
Elisa PoseCIBERehd, Madrid, Spain.
Ramon BatallerCIBERehd, Madrid, Spain.
David LopezGilead Sciences, Foster City, CA, USA.
Anna ZagorskaGilead Sciences, Foster City, CA, USA.
Grant BudasGilead Sciences, Foster City, CA, USA.
Gareth-Rhys JonesCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Calum C BainCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8884-327X
Catalina A VallejosInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3638-1960
Ashis MukhopadhyaDigestive Disorders Department, Aberdeen Royal Infirmary, Aberdeen, UK.
Neil C HendersonCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2273-4094
David C HayCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
James C LeeGenetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.
Laura J PallettInstitute of Infection, Immunity and Transplantation, University College London, London, UK.ORCID http://orcid.org/0000-0002-4161-9462
Volker M LauschkeDepartment of Physiology and Pharmacology, Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Timothy J KendallCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4174-2786
Jonathan A FallowfieldCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Prakash RamachandranCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. prakash.ramachandran@ed.ac.uk.

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101137405EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101170408Guts UK (Core) DGO2019_16Innovate UK TS/R017581/1RCUK | Medical Research Council (MRC) MR/W015919/1Vetenskapsrådet (Swedish Research Council) 2021-02801, 2023-03015, 2024-03401Wellcome Trust (Wellcome) 219542/Z/19/Z
6 · The paper itself

Abstract

Chronic liver disease (CLD) results in liver fibrosis, leading to adverse clinical outcomes. Macrophages regulate fibrosis and represent an attractive therapeutic target. However, the specific macrophage subpopulation that drives fibrosis in CLD remains unclear. Here we generate a liver single-cell atlas comprising 649,295 cells from 42 healthy and 35 CLD patients, identifying 125 transcriptionally distinct cellular states. We resolve two types of disease-expanded TREM2

Indexed as

Liver CirrhosisLiver DiseasesMacrophagesScavenger Receptors, Class AAnimalsChronic DiseaseFemaleHumansLiverMaleMiceScavenger Receptors, Class ESingle-Cell AnalysisOLR1 protein, humanScavenger Receptors, Class AScavenger Receptors, Class E

Identifiers

PMID42806145

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.