ReviewLab animal2026
Exploring Astyanax mexicanus as a model for unraveling genotype-environment interactions and metabolic adaptations.
Review in Lab animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mexican tetra (Astyanax mexicanus), comprising the river-dwelling surface fish and multiple independently evolved cave populations, has emerged as a powerful model for studying the complex interplay between genotype and environment in shaping organismal phenotypes including metabolism. Cavefish have adapted to the extreme conditions of subterranean life-marked by perpetual darkness and limited food availability-through a suite of phenotypes, including eye and pigment loss, enhanced sensory systems, altered sleep and feeding behaviors and remarkable metabolic remodeling. This Perspective brings together major advances over the past two decades in our understanding of these phenotypes, with a focus on the metabolic adaptations used by cavefish. Here we also highlight the experimental tools, web tools and other resources that are expanding the utility of A. mexicanus for mechanistic and translational research. A comparison with other model organisms used in metabolic studies is also included. Finally, we opine how a precision medicine approach to cavefish research can provide insights into human health and disease.
Identifiers
42806163What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.