Evidence map›Paper›PMID 42806505›Full record

ArticleCNS neuroscience & therapeutics2026

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.

F Bezerra, G J D Fernandes, A Anjos-Santos, C A Favoretto, B T Rodolpho, P Palombo, V Vialou, K P Abrahao, F C Cruz

Abstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

F BezerraLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4561-8958
G J D FernandesLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6702-6123
A Anjos-SantosLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7431-7148
C A FavorettoLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8165-7474
B T RodolphoLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0204-5504
P PalomboLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9721-2867
V VialouPrograma de Pós-Graduação em Farmacologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-8212-751X
K P AbrahaoDepartamento de Fisiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4528-2430
F C CruzLaboratory of Molecular and Behavioral Neuroscience, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-3765-7148

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 314336/2023-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES, Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/15505-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/01686-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/24073-3
6 · The paper itself

Abstract

Adolescent impulsivity is linked to increased alcohol seeking and altered activation of anterior insular PV interneurons. Chemogenetic modulation of these neurons regulates inhibitory control and alcohol-related behaviors, highlighting their role in vulnerability to alcohol use disorder.

Indexed as

Drug-Seeking BehaviorGABAergic NeuronsImpulsive BehaviorInsular CortexInterneuronsParvalbuminsAnimalsHumansParvalbuminsadolescencealcoholimpulsivityinsular cortexparvalbumin interneurons

Identifiers

PMID42806505
PMCPMC13620219

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.