Evidence map›Paper›PMID 42807283›Full record

ArticlemicroPublication biology2026

Erik Johnson, Christine A Sedore, Anna L Coleman-Hulbert, Brian D Onken, Vijaya Madhuri Achanta, Yuhua Song, Gino Cortopassi, Gordon J Lithgow, Monica Driscoll, Patrick C Phillips

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erik JohnsonInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon, USA.
Christine A SedoreInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon, USA.
Anna L Coleman-HulbertInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon, USA.
Brian D OnkenDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA.
Vijaya Madhuri AchantaDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA.
Yuhua SongDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA.
Gino CortopassiDepartment of Molecular Biosciences, University of California Davis, Davis, California, USA.
Gordon J LithgowThe Buck Institute for Research on Aging, Novato, California, USA.
Monica DriscollDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA.
Patrick C PhillipsInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon, USA.

Funding

Discovering compounds with robust pro-longevity activitiesU01AG045844 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Gordon J Lithgow · 2013 to 2026
$10.1M
Healthspan Analysis of C. elegans Strains Treated with Candidate Anti Aging InterU01AG045864 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MONICA A. DRISCOLL · 2013 to 2026
$8.1M
Genetic variation underlying the response to longevity interventionsU01AG045829 · NIA · UNIVERSITY OF OREGON · PI Patrick C. Phillips · 2013 to 2026
$8.0M
Caenorhabditis Testing Program Data Coordinating CenterU24AG056052 · NIA · UNIVERSITY OF OREGON · PI Patrick C. Phillips · 2017 to 2026
$2.2M
NIA NIH HHS U01 AG045829NIA NIH HHS U01 AG045844NIA NIH HHS U01 AG045864NIA NIH HHS U24 AG056052
6 · The paper itself

Abstract

The mechanistic target of rapamycin (mTOR), a protein kinase and master cell regulator, is one of the most validated longevity drug targets: mTOR inhibition by compounds like rapamycin has been shown to significantly extend lifespan in numerous model organisms. Here, we tested whether the novel putative mTOR-inhibiting compounds cinnarizine and meclizine could likewise increase lifespan in the nematode

Identifiers

PMID42807283
PMCPMC13617457

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.