ArticleSmall science2026
Catalytic Nitric Oxide-Generating Selenium Nanoparticle-Loaded Hydrogels With Anti-Inflammatory and Pro-Wound-Healing Properties.
Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide's (NO) crucial role in various physiological processes, such as vascular regulation, inflammation, and wound healing, has led to the development of various NO delivery platforms. However, delivering NO in a controlled and sustained manner is challenging due to its short half-life of less than 5 s. To address this challenge, we synthesized polyacrylamide (PAAm) hydrogels loaded with selenium nanoparticles (SeNPs) or polydopamine-coated selenium nanoparticles (Se@PDA NPs), which can catalytically generate NO from both endogenous and exogenous NO donors. Structural characterization confirmed that nanoparticle loading did not alter the intrinsic properties of the PAAm-gel. By adjusting the concentration of NPs loaded within the hydrogels, tunable NO generation was achieved. Both Se-gel and Se@PDA-gel exhibited sustained NO generation, with Se@PDA-gel demonstrating superior recyclability and stability, even after long-term storage under various conditions. The hydrogels exhibited excellent biocompatibility, and their biological activity was validated by elevated interleukin-10 (IL-10) and α-smooth muscle actin (α-SMA) expression, indicating anti-inflammatory effects and potential for wound healing, respectively. These findings establish Se@PDA-gel as a promising platform for controlled and sustained NO delivery, offering therapeutic potential in wound healing and anti-inflammatory therapies, particularly for cardiovascular and infectious diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.